Patient sitting with hands clasped together
Chronic kidney failure is a bit different than acute kidney failure: it develops slowly over a period of weeks, months or years in some patients with kidney disease

A woman is itching her arm

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4. Skin Changes

Itching is a very common side effect of waste build-up in the blood: sometimes it comes with a rash, and sometimes the itch is much deeper in the tissues. In most cases, it’s a general, whole-body itch that persists for a long time. Sometimes the skin will turn a deep yellow color, or take on a brown tint, as well.

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